Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis
نویسندگان
چکیده
منابع مشابه
Defects in cell polarity underlie TSC and ADPKD-associated cystogenesis.
Clinical trials are underway for the treatment of tuberous sclerosis (TSC)-associated tumours using mTOR inhibitors. Here, we show that many of the earliest renal lesions from Tsc1+/- and Tsc2+/- mice do not exhibit mTOR activation, suggesting that pharmacological targeting of an alternative pathway may be necessary to prevent tumour formation. Patients with TSC often develop renal cysts and th...
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Background: Hyper-Immunoglobulin M (IgM) syndrome (HIGM) is a rare primary immunodeficiency in which defective B-cell isotype switching results in a phenotype characterized by elevated or normal serum IgM levels and low levels of other Ig classes, leading to an increased susceptibility to infection, neutropenia, autoimmune disorders, and malignancies. In this disease, a mutation occurs in the C...
متن کاملEP2 receptor mediates PGE2-induced cystogenesis of human renal epithelial cells.
Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by formation of cysts from tubular epithelial cells. Previous studies indicate that secretion of prostaglandin E2 (PGE2) into cyst fluid and production of cAMP underlie cyst expansion. However, the mechanism by which PGE2 directly stimulates cAMP formation and modulates cystogenesis is still unclear, because the particular E-...
متن کاملEpithelial-specific knockout of the Rac1 gene leads to enamel defects.
The Ras-related C3 botulinum toxin substrate 1 (Rac1) gene encodes a 21-kDa GTP-binding protein belonging to the RAS superfamily. RAS members play important roles in controlling focal adhesion complex formation and cytoskeleton contraction, activities with consequences for cell growth, adhesion, migration, and differentiation. To examine the role(s) played by RAC1 protein in cell-matrix interac...
متن کامل[on the Mucosubstance of Enamel Organ].
哺乳動物では,歯 のエナメル質は外胚葉に由来 する唯一の石灰化組織であつて,し かも石灰化の 程度がほかの 中胚葉性 の 硬組織である象牙質, 骨,軟 骨に較べて,は るかに高いとい う特徴をも つている。その上エナメル質はひとたび石灰化が 完了す ると細胞成分 を失ない,生 物学的代謝を全 く営まなくなるとい う点でも骨などとは性質を異 にしている。 したがつてエナメル質の形成に関 し ても,そ れがどのような物質代謝 を基盤としてな され るかということは,ほ かの硬組織との比較の 上から大変興味がもたれている。 一般に骨などの形成 される時には,ま ずコラー ゲンを主体 とする有機基質がつ くられ,そ れが石 灰化の核形成 を誘起して,硬 組織が作 られるもの と考えられている。しかるにエナメル質が形成 さ れる有機質は決してコラーゲンを主体 としたもの ではないし,む しろ最...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2018
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034518779546